It really depends on what the "event" is and your location. Where I am any event that would force me to "bug out" probably killed me already unless it happened when I wasn't home. (reminds me, I need to update the vehicle packs)
But if you are in town then you have to look at the situation on a case by case basis. Loss of services and/or food availability can be ridden out with proper preps. But rioting mobs burning whole neighborhoods are a different thing entirely. The best preps in the world are of no use if they (and you) are on fire. That being said, I would only bug out from any location if hunkering down was, or was about to be, unsafe.
Questions to ask:
How long should I expect the situation to last?
Do I have food/water at home for that long?
Am I safe at home from civil unrest/military crossfire?
Is my location safe from nuclear, chemical, or biological hazards?
Are there any other immanent threats to bugging in (flood, fire, etc.)
And I looked and behold: a pale horse. And his name, that sat on him, was Death. And Hell followed with him.